Calcium homeostasis in pregnant women receiving long-term magnesium sulfate therapy for preterm labor
| Autor: | Pamela A. Burns, Richard J. Schanler, Leon G. Smith |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Bone density chemistry.chemical_element Parathyroid hormone Urine Calcium Radius bone Magnesium Sulfate Calcification Physiologic Obstetric Labor Premature Pregnancy Internal medicine medicine Homeostasis Humans Magnesium Calcium metabolism business.industry Obstetrics and Gynecology Phosphorus General Medicine Urinary calcium Radius medicine.anatomical_structure Endocrinology chemistry Parathyroid Hormone Gestation Female business Copper |
| Zdroj: | American journal of obstetrics and gynecology. 167(1) |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVES: The hypothesis of this study is that calcium homeostasis and bone mineralization are altered in pregnant women receiving long-term therapy with magnesium sulfate as compared with similar women not receiving magnesium sulfate to control preterm labor. STUDY DESIGN: Thirty-nine women between 24 and 32 weeks' gestation, matched for age, race, and duration of bed rest, were enrolled. Indices of calcium homeostasis in serum and urine were measured serially, and bone mineralization of the distal radius was measured at 1 and 11 weeks post partum. RESULTS: Magnesium therapy was administered for a mean duration of 26 ± 14 days and a cumulative dose of 1405 ± 963 gm. Serum concentrations of magnesium, phosphorus, and parathyroid hormone increased and those of calcium decreased from baseline values in the magnesium sulfate group and remained uniform throughout the 3-week investigation. The serum magnesium, phosphorus, parathyroid hormone, and calcium concentrations in the control group were unchanged during the study and differed significantly from those in the magnesium sulfate group (p < 0.001). Urinary output of magnesium, calcium, and copper was significantly greater in the magnesium sulfate group than in the control group throughout the study. Urinary losses of calcium in the magnesium sulfate group, approximately 800 to 900 mglday, were substantial. Although radius bone density 1 week post partum did not differ between groups, the change in bone density from 1 to 11 weeks post partum was significantly lower in the magnesium sulfate group than in controls. CONCLUSIONS: These data suggest that calcium homeostasis is altered during and after long-term magnesium sulfate therapy. The marked, prolonged urinary calcium losses may affect maternal bone mineralization. (AM J OBSTET GVNECOL 1992;167:45-51.) |
| Databáze: | OpenAIRE |
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