Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure

Autor: Pedro Caravaca Perez, José R. González-Juanatey, Jorge Nuche, Lucia Matute-Blanco, Isabel Serrano, Manuel Martínez Selles, Rafael Vázquez García, Luis Martínez Dolz, Manuel Gómez-Bueno, Domingo Pascual Figal, María G. Crespo-Leiro, Álvaro García-Osuna, Jordi Ordoñez-Llanos, Juan Cinca Cuscullola, José M. Guerra, Juan F. Delgado
Přispěvatelé: Redes Temáticas de Investigación Cooperativa en Salud (España)
Rok vydání: 2022
Předmět:
Zdroj: RUC. Repositorio da Universidade da Coruña
Universitat Oberta de Catalunya (UOC)
Frontiers In Cardiovascular Medicine
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 2297-055X
Popis: IntroductionGalectin-3 (Gal-3) is an inflammatory marker associated with the development and progression of heart failure (HF). A close relationship between Gal-3 levels and renal function has been observed, but data on their interaction in patients with acute HF (AHF) are scarce. We aim to assess the prognostic relationship between renal function and Gal-3 during an AHF episode.Materials and MethodsThis is an observational, prospective, multicenter registry of patients hospitalized for AHF. Patients were divided into two groups according to estimated glomerular filtration rate (eGFR): preserved renal function (eGFR ≥ 60 mL/min/1.73 m2) and renal dysfunction (eGFR 2). Cox regression analysis was performed to evaluate the association between Gal-3 and 12-month mortality.ResultsWe included 1,201 patients in whom Gal-3 values were assessed at admission. The median value of Gal-3 in our population was 23.2 ng/mL (17.3–32.1). Gal-3 showed a negative correlation with eGFR (rho = −0.51; p < 0.001). Gal-3 concentrations were associated with higher mortality risk in the multivariate analysis after adjusting for eGFR and other prognostic variables [HR = 1.010 (95%-CI: 1.001–1.018); p = 0.038]. However, the prognostic value of Gal-3 was restricted to patients with renal dysfunction [HR = 1.010 (95%-CI: 1.001–1.019), p = 0.033] with optimal cutoff point of 31.5 ng/mL, with no prognostic value in the group with preserved renal function [HR = 0.990 (95%-CI: 0.964–1.017); p = 0.472].ConclusionsGal-3 is a marker of high mortality in patients with acute HF and renal dysfunction. Renal function influences the prognostic value of Gal-3 levels, which should be adjusted by eGFR for a correct interpretation.
Databáze: OpenAIRE
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