Mesenchymal stromal cell therapy in COPD: from bench to bedside
| Autor: | José Roberto Lapa e Silva, Patricia Rm Rocco, Mariana A. Antunes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Context (language use) Review Mesenchymal Stem Cell Transplantation Pulmonary function testing Lung Disorder Translational Research Biomedical 03 medical and health sciences Pulmonary Disease Chronic Obstructive Internal medicine Medicine Animals Humans Regeneration Lung remodeling COPD business.industry Mesenchymal stem cell Respiratory disease General Medicine Recovery of Function Airway obstruction medicine.disease respiratory tract diseases Disease Models Animal 030104 developmental biology medicine.anatomical_structure emphysema Treatment Outcome Pulmonary Emphysema inflammation repair Airway Remodeling business mesenchymal stromal cells |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 1176-9106 |
| Popis: | COPD is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality. The major risk factor for COPD development is cigarette smoke, and the most efficient treatment for COPD is smoking cessation. However, even after smoking cessation, inflammation, apoptosis, and oxidative stress may persist and continue contributing to disease progression. Although current therapies for COPD (primarily based on anti-inflammatory agents) contribute to the reduction of airway obstruction and minimize COPD exacerbations, none can avoid disease progression or reduce mortality. Within this context, recent advances in mesenchymal stromal cell (MSC) therapy have made this approach a strong candidate for clinical use in the treatment of several pulmonary diseases. MSCs can be readily harvested from diverse tissues and expanded with high efficiency, and have strong immunosuppressive properties. Preclinical studies have demonstrated encouraging outcomes of MSCs therapy for lung disorders, including emphysema. These findings instigated research groups to assess the impact of MSCs in human COPD/emphysema, but clinical results have fallen short of expectations. However, MSCs have demonstrated a good adjuvant role in the clinical scenario. Trials that used MSCs combined with another, primary treatment (eg, endobronchial valves) found that patients derived greater benefit in pulmonary function tests and/or quality of life reports, as well as reductions in systemic markers of inflammation. The present review summarizes and describes the more recent preclinical studies that have been published about MSC therapy for COPD/emphysema and discusses what has already been applied about MSCs treatment in COPD patients in the clinical setting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|