Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators
| Autor: | Nancy A. Monteiro-Riviere, Jim E. Riviere, Jessica P. Ryman-Rasmussen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Mechanical Engineering
Carboxylic Acids Nanoparticle Bioengineering General Chemistry Polyethylene glycol Cell cycle Condensed Matter Physics Endocytosis Polyethylene Glycols chemistry.chemical_compound Surface coating chemistry Biochemistry Quantum dot Quantum Dots PEG ratio Nanoparticles General Materials Science Amines Chemical inhibition Cells Cultured Skin |
| Zdroj: | Nano Letters. 7:1344-1348 |
| ISSN: | 1530-6992 1530-6984 |
| DOI: | 10.1021/nl070375j |
| Popis: | Skin cells (NHEK) take up untargeted quantum dots (QD) with surface polyethylene glycol (PEG), amines, and carboxylic acids, but the mechanisms are unknown. Time courses of QD-NHEK interactions were determined and effects of QD surface coating, temperature, culture medium supplements and inhibitors of the cell cycle and endocytosis identified. The magnitude of QD-NHEK interactions was coating dependent. Low-temperature or unsupplemented medium decreased QD-NHEK interactions. Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells. |
| Databáze: | OpenAIRE |
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