Impaired trophoblast invasion and increased numbers of immune cells at day 18 of pregnancy in the mesometrial triangle of type 1 diabetic rats
| Autor: | Marijke M. Faas, Bart B. L. Groen, G. A. Uuldriks, Thera P. Links, J. T. Visser, de Paul Vos |
|---|---|
| Přispěvatelé: | Man, Biomaterials and Microbes (MBM), Translational Immunology Groningen (TRIGR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Reproductive Origins of Adult Health and Disease (ROAHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Spiral artery GENETICS Placenta Pregnancy in Diabetics Biology Biobreeding diabetes prone rats PHENOTYPE MATERNAL-FETAL INTERFACE Diabetes Mellitus Experimental Spiral artery remodeling Endometrium Immune system Pregnancy Internal medicine Obstetrics and Gynaecology medicine Animals Macrophage Embryo Implantation Lymphocyte Count Lymphocytes Rats Wistar MACROPHAGES Fetus PLACENTATION Immune cells Obstetrics and Gynecology Placentation Trophoblast WOMEN Rats Trophoblasts MODEL Trophoblast invasion Diabetes Mellitus Type 1 Endocrinology medicine.anatomical_structure Type 1 diabetes Reproductive Medicine embryonic structures Gestation Female Developmental Biology |
| Zdroj: | Placenta, 36(2), 142-149. W B SAUNDERS CO LTD |
| ISSN: | 0143-4004 |
| Popis: | Introduction: Type 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight, suggesting impaired placental development. In the present study, we tested the hypothesis that trophoblast invasion and spiral artery (SA) remodeling is impaired in T1D rats ant that this is associated with aberrant local presence of NK cells and macrophages in the mesometrial triangle (MT).Methods: Placentae with MT from pregnant biobreeding diabetes-prone (BBDP; T1D model) rats, control biobreeding diabetes-resistant (BBDR) and Wistar-rats were dissected at day 18 of gestation and stained for trophoblast invasion, SA remodeling, uNK cells and macrophages.Results: Interstitial trophoblast invasion and SA remodeling was impaired in BBDP-rats vs. control rats, coinciding with increased presence of NK cells and an increased iNOS+/CD206+ ratio of macrophages.Discussion: Decreased fetal and placental weight in BBDP-rats was associated with diminished interstitial trophoblast invasion and less optimal SA remodeling, increased numbers of NK cells and increased iNOS+/CD206+ macrophage ratio in the MT of BBDP-rats.Conclusions: The impaired trophoblast invasion and SA remodeling may be due to an aberrant local immune-response and may result in damage to the fetal placenta and insufficient supply of nutrients towards the fetus with eventually decreased fetal weight as a consequence. (C) 2014 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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