Autoimmune Sensorineural Hearing Loss in Young Patients: An Exploratory Study
| Autor: | Naima Deggouj, Michel Gersdorff, Alain Lona, Jean-Paul Tomasi |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Hearing loss Hearing Loss Sensorineural Immunoblotting Exploratory research Audiology medicine.disease_cause Autoimmune Diseases Autoimmunity otorhinolaryngologic diseases medicine Humans Autoimmune sensorineural hearing loss Young adult Child Autoantibodies Autoimmune disease biology business.industry medicine.disease Otorhinolaryngology Case-Control Studies Child Preschool biology.protein Female Sensorineural hearing loss medicine.symptom Antibody business Myelin P0 Protein |
| Zdroj: | The Laryngoscope. 111:2050-2053 |
| ISSN: | 0023-852X |
| DOI: | 10.1097/00005537-200111000-00034 |
| Popis: | OBJECTIVES: P0 protein is expressed exclusively in myelinating Schwann cells of the peripheral nervous system. In a previous study from our laboratory, 27% of patients with sensorineural hearing loss (SNHL) had antibodies to P0 protein in their serum. The purpose of the present exploratory study was to examine the relationship between the clinical presentation of SNHL among children and young adults (age range, 5-30 y) and the presence of serum anti-P0 antibodies. STUDY DESIGN: The data were collected by retrospective questionnaires from Belgian otolaryngologists. METHODS: Patients were divided for comparison into two groups according to the presence or absence of anti-P0 antibodies. RESULTS: Analyses of clinical data and audiometric results indicated that a progressive hearing loss was more frequently recorded in the patients in the anti-P0 antibody-positive group (82% [14 of 17]) than in those in the anti-P0 antibody-negative group (35% [6 of 17]) (P |
| Databáze: | OpenAIRE |
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