Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort
Autor: | Carlos González, Kim Overvad, Francesca L. Crowe, Isabelle Romieu, Lea Bredsdorff, Raul Zamora-Ros, Augustin Scalbert, Krasimira Aleksandrova, Florence Perquier, Guri Skeie, Veronika Fedirko, Maria-Dolores Chirlaque, Annekatrin Lukanova, Eric J. Duell, Leila Lujan-Barroso, Pilar Amiano, Rosario Tumino, Anette Hjartåker, Fulvio Ricceri, Valeria Pala, Guy Fagherazzi, H. Bas Bueno-de-Mesquita, Rikard Landberg, Marcial Argüelles, A. Mattiello, Elio Riboli, Aurelio Barricarte, Antonia Trichopoulou, Esther Vermeulen, Nicholas J. Wareham, Gianna Ziara, Anne M. May, Elisabete Weiderpass, Effie Vasilopoulou, Marina Touillaud, Petra H.M. Peeters, Verena A. Grote, Ulrika Ericson, Jytte Halkjær, Emily Sonestedt, Kay Thee Khaw, Anne Tjønneland, Esther Molina-Montes, Peter D. Siersema, Heiner Boeing, Calogero Saieva, I. Johansson |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms Epidemiology Flavonoid Adenocarcinoma Gastroenterology Diet Surveys Risk Assessment Flavonols Internal medicine Medicine Humans Multicenter Studies as Topic Prospective Studies Registries Aged Proportional Hazards Models chemistry.chemical_classification Flavonoids business.industry Hazard ratio Smoking Esophageal cancer Middle Aged medicine.disease Confidence interval European Prospective Investigation into Cancer and Nutrition Surgery Diet Europe chemistry Cohort Carcinoma Squamous Cell Female business Biomedical sciences |
Zdroj: | Vermeulen, E, Zamora-Ros, R, Duell, E J, Luján-Barroso, L, Boeing, H, Aleksandrova, K, Bueno-de-Mesquita, H B, Scalbert, A, Romieu, I, Fedirko, V, Touillaud, M, Fagherazzi, G, Perquier, F, Molina-Montes, E, Chirlaque, M-D, Vicente Argüelles, M, Amiano, P, Barricarte, A, Pala, V, Mattiello, A, Saieva, C, Tumino, R, Ricceri, F, Trichopoulou, A, Vasilopoulou, E, Ziara, G, Crowe, F L, Khaw, K-T, Wareham, N J, Lukanova, A, Grote, V A, Tjønneland, A, Halkjær, J, Bredsdorff, L, Overvad, K, Siersema, P D, Peeters, P H M, May, A M, Weiderpass, E, Skeie, G, Hjartåker, A, Landberg, R, Johansson, I, Sonestedt, E, Ericson, U, Riboli, E & González, C A 2013, ' Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort ', American Journal of Epidemiology, vol. 178, no. 4, pp. 570-81 . https://doi.org/10.1093/aje/kwt026 |
Popis: | We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers. |
Databáze: | OpenAIRE |
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