Consequence of restaging after neoadjuvant treatment for locally advanced rectal cancer
| Autor: | Johannes G. M. Burgerhof, Geke A. P. Hospers, J. C. Beukema, Jolien J J Tjalma, Juda Vecht, Derk Jan A. de Groot, Shekar V. K. Mahesh, W. H. de Vos Tot Nederveen Cappel, J.W.B. de Groot, Gursah Kats-Ugurlu, E. M. Wiegman, M. G. Havenith, Cees Bisschop, Klaas Havenga, B. van Etten, D. Van Geldere, M. Van't Veer-ten Kate |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Life Course Epidemiology (LCE), Robotics and image-guided minimally-invasive surgery (ROBOTICS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Locally advanced GUIDELINES COLORECTAL-CANCER CHEMORADIOTHERAPY Surgical oncology Neoadjuvant treatment medicine MANAGEMENT Humans Aged Neoplasm Staging Retrospective Studies PREOPERATIVE RADIOTHERAPY Aged 80 and over Rectal Neoplasms business.industry PULMONARY METASTASES Rectum Chemoradiotherapy Adjuvant Middle Aged medicine.disease Total mesorectal excision Neoadjuvant Therapy Confidence interval medicine.anatomical_structure Oncology Abdomen Female Surgery Radiology Tomography X-Ray Computed business Chemoradiotherapy CT |
| Zdroj: | Annals of Surgical Oncology, 22(2), 552-556. SPRINGER |
| ISSN: | 1068-9265 |
| Popis: | Locally advanced rectal cancer is customarily treated with neoadjuvant chemoradiotherapy (CRT) followed by a total mesorectal excision. During the course of CRT, previously non-detectable distant metastases can appear. Therefore, a restaging CT scan of the chest and abdomen was performed prior to surgery. The aim of this study was to determine the frequency of a change in treatment strategy after this restaging CT scan.Patients treated with neoadjuvant CRT for locally advanced rectal cancer between January 2003 and July 2013 were included retrospectively. To determine the value of the restaging CT scan, the surgical treatment as planned before CRT was compared with the treatment ultimately received.A total of 153 patients (91 male) were eligible, and median age was 62 (32-82) years. The restaging CT scan revealed the presence of distant metastases in 19 patients (12.4, 95 % confidence interval [CI] 7.0-17.8). In 17 patients (11.1, 95 % CI 6.1-16.1), a change in treatment strategy occurred due to the detection of metastases with a restaging CT scan.A restaging CT scan after completion of neoadjuvant CRT may detect newly developed metastases and consequently alter the initial treatment strategy. This study demonstrated the added value of the restaging CT scan prior to surgery. |
| Databáze: | OpenAIRE |
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