Modeling dynamics in diseased cardiac tissue: Impact of model choice
| Autor: | Craig S. Henriquez, Eli Medvescek, Tanmay A. Gokhale |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Discretization 0206 medical engineering General Physics and Astronomy 02 engineering and technology 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Path length Fibrosis medicine Focus Issue: Complex Cardiac Dynamics Model choice Mathematical Physics Continuous modelling Applied Mathematics Dynamics (mechanics) Critical factors Models Cardiovascular Heart Statistical and Nonlinear Physics medicine.disease 020601 biomedical engineering Tissue fibrosis Collagen Biological system |
| Zdroj: | Chaos: An Interdisciplinary Journal of Nonlinear Science. 27:093909 |
| ISSN: | 1089-7682 1054-1500 |
| DOI: | 10.1063/1.4999605 |
| Popis: | Cardiac arrhythmias have been traditionally simulated using continuous models that assume tissue homogeneity and use a relatively large spatial discretization. However, it is believed that the tissue fibrosis and collagen deposition, which occur on a micron-level, are critical factors in arrhythmogenesis in diseased tissues. Consequently, it remains unclear how well continuous models, which use averaged electrical properties, are able to accurately capture complex conduction behaviors such as re-entry in fibrotic tissues. The objective of this study was to compare re-entrant behavior in discrete microstructural models of fibrosis and in two types of equivalent continuous models, a homogenous continuous model and a hybrid continuous model with distinct heterogeneities. In the discrete model, increasing levels of tissue fibrosis lead to a substantial increase in the re-entrant cycle length which is inadequately reflected in the homogenous continuous models. These cycle length increases appear to be primarily due to increases in the tip path length and to altered restitution behavior, and suggest that it is critical to consider the discrete effects of fibrosis on conduction when studying arrhythmogenesis in fibrotic myocardium. Hybrid models are able to accurately capture some aspects of re-entry and, if carefully tuned, may provide a framework for simulating conduction in diseased tissues with both accuracy and efficiency. |
| Databáze: | OpenAIRE |
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