Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer
| Autor: | Mev Dominguez-Valentin, Ke Borg, Eva Rambech, Christina Therkildsen, Anja Nissen, Göran Jönsson, Britta Halvarsson, Mef Nilbert, Inge Bernstein |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Familial Colorectal Cancer Type X DNA Copy Number Variations Colorectal cancer Chromosomes Human Pair 20 Biology Sensitivity and Specificity Diagnosis Differential Chromosome 18 Internal medicine Gene Duplication Gene duplication medicine Humans Aged Aged 80 and over Chromosome Aberrations Family Health Comparative Genomic Hybridization Chromosome Microsatellite instability Reproducibility of Results Middle Aged medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Lynch syndrome Chromosomal region Female Chromosome Deletion Chromosomes Human Pair 18 Colorectal Neoplasms |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 49(6) |
| ISSN: | 1879-0852 |
| Popis: | Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with FCCTX from Lynch syndrome, which likely signifies different preferred tumourigenic pathways. |
| Databáze: | OpenAIRE |
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