A case of corticosteroid‐refractory adult‐onset Still's disease successfully controlled with tocilizumab despite transient neutropenia and thrombocytopenia
| Autor: | Aiko Takano, Jun-ichi Iwata, Hitomi Yamamura, Yoshihito Horiuchi |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adult-onset Still's disease business.industry medicine.drug_class thrombocytopenia Dermatology RC581-607 Neutropenia medicine.disease Gastroenterology tocilizumab chemistry.chemical_compound Tocilizumab Refractory chemistry RL1-803 Internal medicine hyperferritinemia medicine neutropenia Immunology and Allergy Corticosteroid Immunologic diseases. Allergy business adult‐onset Still's disease |
| Zdroj: | Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 3, Pp 62-66 (2021) |
| ISSN: | 2574-4593 |
| Popis: | We report a case of a 50‐year‐old woman with adult‐onset Still's disease (AOSD). Even after receiving steroid pulse therapy and high‐dose oral corticosteroid medication, the patient's serum ferritin level increased, while the number of neutrophils and platelets decreased. However, fever, erythema, sore throat, and arthralgia ceased. Therefore, we administered intravenous tocilizumab (TCZ). However, neutropenia, thrombocytopenia, and exacerbation of hyperferritinemia occurred after the first TCZ infusion. After the second TCZ infusion, the values returned to normal, and we discontinued prednisolone successfully without any flare‐ups of AOSD. We reviewed case reports describing adverse events after TCZ administration in AOSD patients. |
| Databáze: | OpenAIRE |
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