Effects of opiates on the discriminative stimulus properties of dopamine agonists
| Autor: | James B. Appel, Alice M. Holohean, Linda L. Hernandez |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Narcotics Pentazocine medicine.medical_specialty Time Factors Apomorphine Dopamine Clinical Biochemistry Pharmacology Stimulus (physiology) Toxicology Biochemistry Behavioral Neuroscience Discrimination Psychological Internal medicine medicine Animals Amphetamine Biological Psychiatry Morphine Chemistry Naltrexone Rats Endocrinology Haloperidol Opiate Stimulus control medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 9:459-463 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(78)90041-2 |
| Popis: | Two groups of rats were trained to discriminate the dopamine agonists amphetamine (0.75 mg/kg) or apomorphine (0.38 mg/kg) from saline in a two-lever operant task. Various doses of morphine and pentazocine were tested for generalization to and interference with the discriminative stimulus complexes produced by the dopamine agonists. Low doses of morphine appeared to produce a stimulus complex which is similar to that produced by apomorphine, but which differs from that produced by amphetamine. Pentazocine showed no evidence of generalization to either the apomorphine or the amphetamine cue. Neither opiate interfered with the discriminative stimuli produced by the dopamine agonists, although decreases in the number of animals responding occured. |
| Databáze: | OpenAIRE |
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