RETINAL BLOOD FLOW AFTER INTRAVITREAL BEVACIZUMAB IS A PREDICTIVE FACTOR FOR OUTCOMES OF MACULAR EDEMA ASSOCIATED WITH CENTRAL RETINAL VEIN OCCLUSION
| Autor: | Takashi Kitaoka, Kiyoshi Suzuma, Eiko Tsuiki, Yoshihisa Yamada, Makiko Matsumoto, Azusa Fujikawa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Visual acuity Time Factors Visual Acuity Angiogenesis Inhibitors chemistry.chemical_compound 0302 clinical medicine Central retinal vein occlusion blood flow Original Study Fluorescein Angiography medicine.diagnostic_test central retinal vein occlusion General Medicine Fluorescein angiography Prognosis Treatment Outcome Intravitreal Injections Female medicine.symptom Blood Flow Velocity Tomography Optical Coherence medicine.drug medicine.medical_specialty Bevacizumab bevacizumab Macular Edema 03 medical and health sciences Ophthalmology Retinal Vein Occlusion medicine Humans Macular edema Retrospective Studies business.industry Retrospective cohort study Retinal Blood flow medicine.disease eye diseases Surgery 030104 developmental biology Receptors Vascular Endothelial Growth Factor chemistry Regional Blood Flow 030221 ophthalmology & optometry business Follow-Up Studies |
| Zdroj: | Retina (Philadelphia, Pa.) |
| ISSN: | 1539-2864 |
| Popis: | A retrospective observational case series study of 44 nonischemic central retinal vein occlusion (CRVO) patients was conducted and visual acuity, central retinal thickness, and blood flow were determined via the use of laser speckle flowgraphy. This study shows that blood flows after intravitreal bevacizumab can predict outcomes in patients with CRVO. Purpose: To investigate whether retinal blood flow levels after intravitreal bevacizumab (IVB) treatment are correlated with the outcomes of patients with macular edema secondary to central retinal vein occlusion. Methods: This retrospective observational case study enrolled 44 cases nonischemic central retinal vein occlusion. In each patient, visual acuity, central retinal thickness, and mean blur rate, which was measured by laser speckle flowgraphy and represents retinal blood flow velocity, were examined. Results: At the end of the follow-up period (19.8 ± 8.8 months), 4 of 44 eyes (9.1%) converted to the ischemic type (converted group), whereas 40 (90.9%) remained unchanged (nonischemic group). Mean central retinal thickness significantly decreased and mean visual acuity significantly improved at 1 month after the first IVB injection in each group. Mean mean blur rate in the nonischemic group significantly increased, whereas it was unchanged in the converted group. The difference between the two groups was already significant after the first IVB injection. Subsequently, visual acuity worsened in the converted group. Multiple linear regression analysis indicated that the strongest correlation was between the last visual acuity and the last mean blur rate. Conclusion: Blood flow measurements are useful for evaluating IVB treatments. Blood flow after IVB can predict outcomes in patients with central retinal vein occlusion. |
| Databáze: | OpenAIRE |
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