Design, synthesis and antiproliferative activity against human cancer cell lines of novel benzo-, benzofuro-, azolo- and thieno-1,3-thiazinone resorcinol hybrids
| Autor: | Monika Karpińska, Joanna Wietrzyk, Wojciech Rzeski, Małgorzata Juszczak, Andrzej Niewiadomy, Joanna Matysiak, Alicja Skrzypek, Dagmara Klopotowska, Beata Paw |
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| Rok vydání: | 2019 |
| Předmět: |
Cisplatin
Chemistry(all) Stereochemistry General Chemical Engineering In silico Substituent Antiproliferative activity General Chemistry Resorcinol Heterocyclic resorcinols lcsh:Chemistry chemistry.chemical_compound ADMET Benzenediol lcsh:QD1-999 chemistry Cell culture 4H-3 1-Benzothiazin-4-ones Chemical Engineering(all) medicine Potency Moiety SAR medicine.drug |
| Zdroj: | Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 2655-2667 (2019) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2015.05.006 |
| Popis: | In this paper we report the design and synthesis of novel derivatives of the 4H-3,1-benzothiazinone type and heterocyclic analogues, i.e. benzofuro-, azolo- and thieno-1,3-thiazin-4-ones possessing 2,4-dihydroxyphenyl substituent. The compounds were obtained by the one-step reaction of aminobenzamides or heterocyclic aminocarboxamides with aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione]. Evaluation of their antiproliferative potency against human cancer cell lines showed that the activity of some analogues was similar to that of cisplatin. The highest activity and low toxicity were found for 6-tert-butyl-2-(5-chloro-2,4-dihydroxyphenyl)-4H-thieno[3,2-d][1,3]thiazin-4-one. The structure–activity elucidation reveals that the most active compounds are those with a thienothiazin-4-one and benzofuro[3,2-d][1,3]thiazin-4-one skeleton and the presence of the hydrophobic substituent (Et, Cl) in the benzenediol moiety increases their antiproliferative potency. The ADMET properties of selected compounds including metabolic stability and toxicity profile were estimated in silico. Keywords: 4H-3,1-Benzothiazin-4-ones, Heterocyclic resorcinols, SAR, Antiproliferative activity, ADMET, In silico |
| Databáze: | OpenAIRE |
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