The impact of preoperative MRI-based apparent diffusion coefficients on local recurrence and outcome in patients with cerebral metastases
| Autor: | Michael Sabel, Hans-Jakob Steiger, Marion Rapp, Marcel A. Kamp, Bernd Turowski, Julia Steinmann, Franziska Staub-Bartelt, Hosai Sadat, Daniel Hänggi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry General Medicine Outcome (game theory) 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Overall survival Surgery In patient Neurology (clinical) Radiology Diffusion (business) business 030217 neurology & neurosurgery |
| Zdroj: | British journal of neurosurgery. |
| ISSN: | 1360-046X |
| Popis: | Surgery of single cerebral metastases is standard but frequently fails to achieve local tumour control. Reliable predictors for local tumour progression and overall survival are unknown. MRI-based apparent diffusion coefficients (ADC) correlate with tumour cellularity and invasion. The present study analysed a potential relation between the MRI based apparent diffusion coefficients local recurrence and outcome in patients with brain metastases.A retrospective analysis was performed for patients with cerebral metastases and complete surgical resection evaluated by an early postoperative MRI72h. Minimal ADC and mean ADC were assessed in preoperative 1,5T-MRI scans by placing regions of interests in the tumour and the peritumoural tissue.Analysis of the relation between ADC values, local progression and outcome was performed in 86 patients with a mean age of 59 years (range 33-83 years). Primary site was NSCLC in 37.2% of all cases. Despite complete resection 33.7% of all patients suffered from local in-brain-progression. There were no significant differences in ADC values in groups based on histology. In the present cohort, the mean ADCmin and the mean ADCmean within the metastasis did not differ significantly between patients with and without a later local in-brain progression (634 × 10In the present study analysed ADC values had no significant impact on local in brain progression and survival parameters. |
| Databáze: | OpenAIRE |
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