Distribution of Chlamydia trachomatis genotypes in neonatal conjunctivitis in Hungary
| Autor: | Eszter Balla, Tímea Erdősi, Judit Henczkó, Andrea Balázs, Edit Urbán, Fruzsina Petrovay, Gilbert G.G. Donders |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Ophthalmia Neonatorum medicine.medical_specialty Genotype 030106 microbiology Ophthalmia Chlamydia trachomatis medicine.disease_cause Polymerase Chain Reaction Microbiology Neonatal conjunctivitis 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Prevalence medicine Humans 030212 general & internal medicine Biology Dominance (genetics) Hungary Molecular Epidemiology Molecular epidemiology business.industry Age Factors Infant Newborn Infant Sequence Analysis DNA General Medicine Conjunctivitis Inclusion medicine.disease Immunology Female business |
| Zdroj: | Journal of medical microbiology |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.000523 |
| Popis: | The objective of the present study was to determine the frequency and age distribution of different Chlamydia trachomatis (CT) genotypes causing ophthalmia neonatorum (ON) in Hungary. Using CT specific PCR, we tested 76 conjunctival samples from symptomatic infants up to 3 months old in the National Centre for Epidemiology, Budapest between 2008 and 2016. CT tested positive in 30 of 76 conjunctival samples (39.5 %). The sequencing of the positive samples was successful in every case but one, and resulted in 48% dominance for genotype E (14/29), followed by 24% for genotype G (7/29), 10% for J (3/29), 6.9% for K and F (2/29), and 3.4% for H (1/29). CT must still be regarded as a common pathogen causing ON in Hungary. Routine screening and treatment of pregnant women can be recommended to prevent these conditions. Chronic ON cases can be reduced by early diagnosis. Further research is needed to explain the dominance of genotypes E and G. |
| Databáze: | OpenAIRE |
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