Does locally delivered Zoledronate influence peri-implant bone formation? - Spatio-temporal monitoring of bone remodeling in vivo
| Autor: | Julien Ston, Eric Thein, Dominique P. Pioletti, Philip Procter, Ulrike Kettenberger |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Dynamic histomorphometry Bone Screws Biophysics Bioengineering Peri implant bone MicroCT Zoledronic Acid Bone resorption Hydrogel Polyethylene Glycol Dimethacrylate Bone remodeling Biomaterials Bone volume fraction chemistry.chemical_compound Drug Delivery Systems In vivo Bone Density Osteogenesis Hyaluronic acid Bisphosphonate Animals Femur Bone Resorption Bone Density Conservation Agents Diphosphonates Imidazoles Implant Resorption Rats Hydrogel chemistry Mechanics of Materials Drug delivery Ceramics and Composites Ovariectomized rat Female Biomedical engineering |
| Zdroj: | Biomaterials. 35(37) |
| ISSN: | 1878-5905 |
| Popis: | Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronate-loaded hydrogel for enhancement of peri-implant bone volume which is directly linked to improved implant fixation. |
| Databáze: | OpenAIRE |
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