The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
| Autor: | Asaf Salamov, Heidrun Gundlach, Stephan Ossowski, Magnus Nordborg, Jan Fang Cheng, Jesse D. Hollister, Tina T. Hu, Mikhail E. Nasrallah, Igor V. Grigoriev, Detlef Weigel, Korbinian Schneeberger, James C. Carrington, Noah Fahlgren, Manuel Spannagl, Jane Grimwood, Brandon S. Gaut, Jeremy Schmutz, Yves Van de Peer, E. G. Bakker, Georg Haberer, Liang Yang, Ya-Long Guo, Klaus F. X. Mayer, Joy Bergelson, Richard M. Clark, Robert P. Ottilar, Jeffrey A. Fawcett, Xi-Mo Wang, Jun Cao, Pedro Pattyn |
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| Rok vydání: | 2011 |
| Předmět: |
0106 biological sciences
Genome evolution DNA Plant Centromere Molecular Sequence Data Arabidopsis 01 natural sciences Genome Article Chromosomes Plant Evolution Molecular 03 medical and health sciences Species Specificity Sequence Homology Nucleic Acid Gene density Genetics Arabidopsis lyrata Genome size Gene 030304 developmental biology Whole genome sequencing 0303 health sciences Base Sequence Models Genetic biology fungi food and beverages Genome project biology.organism_classification Genome Plant 010606 plant biology & botany |
| Zdroj: | Nature genetics |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng.807 |
| Popis: | We report the 207-Mb genome sequence of the North American Arabidopsis lyrata strain MN47 based on 8.3× dideoxy sequence coverage. We predict 32,670 genes in this outcrossing species compared to the 27,025 genes in the selfing species Arabidopsis thaliana. The much smaller 125-Mb genome of A. thaliana, which diverged from A. lyrata 10 million years ago, likely constitutes the derived state for the family. We found evidence for DNA loss from large-scale rearrangements, but most of the difference in genome size can be attributed to hundreds of thousands of small deletions, mostly in noncoding DNA and transposons. Analysis of deletions and insertions still segregating in A. thaliana indicates that the process of DNA loss is ongoing, suggesting pervasive selection for a smaller genome. The high-quality reference genome sequence for A. lyrata will be an important resource for functional, evolutionary and ecological studies in the genus Arabidopsis. |
| Databáze: | OpenAIRE |
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