Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice
| Autor: | Keiko Yamato, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Mayuko Monden, Yuu Ishimori, Takaharu Nomura, Akihiro Sakoda, Kiyonori Yamaoka, Junichi Teraoka |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Lipid Peroxides
Immunology Inflammation Pharmacology Nitric Oxide Nitric oxide Superoxide dismutase Mice chemistry.chemical_compound Edema medicine Animals Immunology and Allergy Mice Inbred ICR antioxidative function biology Inhalation Superoxide Dismutase Tumor Necrosis Factor-alpha Catalase Carrageenan respiratory tract diseases chemistry Radon inflammation biology.protein carrageenan Female Tumor necrosis factor alpha medicine.symptom edema radon inhalation |
| Zdroj: | Inflammation. 35(2):713-722 |
| ISSN: | 0360-3997 |
| Popis: | We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema. |
| Databáze: | OpenAIRE |
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