TRPV1-mediated itch in seasonal allergic rhinitis

Autor: Edward D. Högestätt, Peter M. Zygmunt, Lennart Greiff, Lisa Alenmyr
Rok vydání: 2009
Předmět:
Adult
Allergy
Nasal Provocation Tests
Polyunsaturated Alkamides
medicine.medical_treatment
Immunology
TRPV1
TRPM Cation Channels
TRPV Cation Channels
Nerve Tissue Proteins
Stimulation
Arachidonic Acids
Severity of Illness Index
Nasal provocation test
chemistry.chemical_compound
Transient Receptor Potential Channels
otorhinolaryngologic diseases
TRPM8
Humans
Plant Oils
Immunology and Allergy
Medicine
Acrolein
TRPA1 Cation Channel
business.industry
Pruritus
Anti-Inflammatory Agents
Non-Steroidal
Rhinitis
Allergic
Seasonal
Antipruritics
Allergens
Calcium Channel Blockers
medicine.disease
Menthol
medicine.anatomical_structure
chemistry
Capsaicin
Sensory System Agents
lipids (amino acids
peptides
and proteins)
Calcium Channels
business
psychological phenomena and processes
Endocannabinoids
Mustard Plant
Respiratory tract
Zdroj: Allergy. 64:807-810
ISSN: 1398-9995
0105-4538
DOI: 10.1111/j.1398-9995.2009.01937.x
Popis: Background: Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). Aim of the study: To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. Methods: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Moreover, challenges were performed with mustard oil (allylisothiocyanate) and cinnamaldehyde as well as menthol, activators of TRPA1 and TRPM8, respectively. Nasal symptoms were monitored after each challenge and compared with symptoms reported following corresponding sham challenges. Symptoms recorded after challenge prior to pollen season were also compared with challenge-induced symptoms during pollen season. Results: The TRPV1, TRPA1 and TRPM8-activators produced sensory symptoms dominated by pain and smart. During seasonal allergen exposure, but not prior to season, TRPV1-activators also induced itch. Furthermore, the seasonal challenge to the TRPV1-activator olvanil was associated with rhinorrhoea. Conclusion: Patients with allergic rhinitis feature an increased itch response to TRPV1 stimulation at seasonal allergen exposure. We suggest that this reflects part of the hyperresponsiveness that characterizes on-going allergic rhinitis. Intervention with the TRPV1-signalling pathway may offer potential treatments of this condition.
Databáze: OpenAIRE
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