Lac dye as a potential anti-neoplastic agent
| Autor: | Kewal Krishan Sharma, Sanjeev Kumar Ranjan, Dev Mani Pandey, Gulsaz Shamim, R. Ramani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
HL60
Antineoplastic Agents 02 engineering and technology laccaic acid 010501 environmental sciences anticancer 01 natural sciences Jurkat cells Anthraquinone lcsh:RC254-282 chemistry.chemical_compound pigment Cell Line Tumor hemic and lymphatic diseases Anthraquinones medicine Humans Radiology Nuclear Medicine and imaging Cell Proliferation 0105 earth and related environmental sciences biology General Medicine 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Molecular biology Leukemia Oncology chemistry Cell culture 0210 nano-technology Azo Compounds Kerria lacca K562 cells |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 12, Iss 2, Pp 1033-1035 (2016) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Objective: Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr). Materials and Methods: In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six human leukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay. Results and Conclusion: Both crimson and yellow lac dye inhibits proliferation of Human leukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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