Glomerular filtration rate, blood pressure and microalbuminuria in adults born SGA: A 5-year longitudinal study after cessation of GH treatment
| Autor: | Wesley J Goedegebuure, Gerthe F. Kerkhof, Anita C. S. Hokken-Koelega |
|---|---|
| Přispěvatelé: | Pediatrics, Erasmus MC other |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system Renal function Blood Pressure Gestational Age 030209 endocrinology & metabolism Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Pregnancy Albumins Internal medicine medicine Albuminuria Humans Longitudinal Studies reproductive and urinary physiology Creatinine business.industry medicine.disease female genital diseases and pregnancy complications Growth hormone treatment Low birth weight Blood pressure chemistry Growth Hormone 030220 oncology & carcinogenesis Infant Small for Gestational Age Small for gestational age Female Microalbuminuria medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Clinical Endocrinology, 91(6), 892-898. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | Background: Growth hormone treatment increases glomerular filtration rate (GFR), as serum IGF-I stimulates the renin-angiotensin system. Infants born with a low birth weight have a smaller number of nephrons, which cause a lower GFR, a higher blood pressure and a higher albumin-to-creatinine ratio in early adulthood. Method: A total of 261 young adults born SGA, previously treated with growth hormone (SGA-GH), were longitudinally followed. Glomerular filtration rate, based on serum creatinine levels, was determined at cessation of GH treatment and at 6 months, 2 years and 5 years thereafter. Glomerular filtration rate, blood pressure and urinary albumin-to-creatinine ratio at 5 years after cessation of GH were compared with untreated age-matched controls (56 untreated short subjects born SGA [SGA-S], 118 subjects born SGA with spontaneous catch-up growth [SGA-CU], 135 subjects born appropriate for gestational age [AGA]). Results: Glomerular filtration rate decreased significantly only during the first 6 months after cessation of GH treatment, while remaining well within the normal range (124.6 vs 120.2 mL/min/1.73 m2, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text