Environmental factors in inflammatory bowel disease: A case-control study based on a Danish inception cohort
| Autor: | Tanja Stenbaek Hansen, Tine Jess, I. Vind, Malene Fey Nielsen, Michael Gamborg, Pia S. Munkholm, Margarita Elkjaer |
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| Rok vydání: | 2011 |
| Předmět: |
Dietary Fiber
medicine.medical_specialty Denmark Environment Inflammatory bowel disease Gastroenterology Cohort Studies Crohn Disease Dietary Sucrose Risk Factors Surveys and Questionnaires Internal medicine Odds Ratio medicine Appendectomy Humans Tonsillectomy Pertussis Vaccine Crohn's disease business.industry Smoking Case-control study General Medicine Odds ratio medicine.disease Ulcerative colitis Poliovirus Vaccines Breast Feeding Logistic Models Case-Control Studies Cohort Etiology Colitis Ulcerative business Measles Cohort study |
| Zdroj: | Journal of Crohn's and Colitis. 5:577-584 |
| ISSN: | 1873-9946 |
| DOI: | 10.1016/j.crohns.2011.05.010 |
| Popis: | Background The role of environmental factors in development of inflammatory bowel disease (IBD) remains uncertain. The aim of the present study was to assess a number of formerly suggested environmental factors in a case-control study of an unselected and recently diagnosed group of patients with IBD and a control group of orthopaedic patients. Methods A total of 123 patients diagnosed with Crohn's disease (CD) and 144 with ulcerative colitis (UC) in Copenhagen (2003–2004) were matched 1:1 on age and gender to 267 orthopaedic controls. Participants received a questionnaire with 87 questions concerning environmental factors prior to IBD/orthopaedic admission. Odds ratios (OR) were calculated by logistic regression. Results Being breastfed > 6 months (OR, 0.50; 95% CI, 0.23–1.11) and undergoing tonsillectomy (OR, 0.49; 95% CI, 0.31–0.78) decreased the odds for IBD, whereas appendectomy decreased the odds for UC only (OR, 0.29; 95% CI, 0.12–0.71). Vaccination against pertussis (OR, 2.08; 95% CI, 1.07–4.03) and polio (OR, 2.38; 95% CI, 1.04–5.43) increased the odds for IBD, whereas measles infection increased the odds for UC (OR, 3.50; 95% CI, 1.15–10.6). Low consumption of fibres and high consumption of sugar were significantly associated with development of CD and UC. Smoking increased the risk for CD and protected against UC. Conclusion Among Danish patients with CD and UC belonging to an unselected cohort, disease occurrence was found to be associated both with well-known factors such as smoking and appendectomy, and with more debated factors including breastfeeding, tonsillectomy, childhood vaccinations, childhood infections, and dietary intake of fibres and sugar. |
| Databáze: | OpenAIRE |
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