Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure
| Autor: | Hassan Ghasemi, Tooba Ghazanfari, Mohammad Ali Javadi, Sussan K. Ardestani, Jalaledin Shams, Mohamad Reza Sedighi moghadam, Fatemeh Heidary, Shamsa Shariatpanahi, Raheleh Shakeri, Mahmoud Mahmoudi, Mohammad Mehdi Naghizadeh, Roya Yaraee, Faramarz Falahi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty P-selectin Immunology Intercellular Adhesion Molecule-1 Iran Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Eye Injuries Internal medicine E-selectin Mustard Gas medicine Immunology and Allergy Humans Chemical Warfare Agents Veterans Pharmacology ICAM-1 biology Cell adhesion molecule business.industry Environmental Exposure Middle Aged eye diseases 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Toxicity biology.protein L-selectin sense organs business Cell Adhesion Molecules Selectin |
| Zdroj: | International immunopharmacology. 76 |
| ISSN: | 1878-1705 |
| Popis: | Introduction In this study, the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), P-, E-, and L-selectins were investigated in seriously eye-injured patients exposed to sulfur mustard (SM). Material and methods A total of 128 individuals with SM-induced serious eye injuries and 31 healthy male controls were included in this study. The serum concentration of soluble forms of adhesion molecules was measured by enzyme-linked immunosorbent assay (ELISA) method. Result The serum level of soluble ICAM-1 was significantly higher in the SM-exposed individuals with an abnormality in tear meniscus height, corneal verticillata, and pannus compared with SM-exposed individuals without these abnormalities. There were no significant differences in the level of all three measured selectins between the SM-exposed group and the control groups. SM-exposed individuals with corneal defect had a significantly higher level of soluble E-selectin than SM-exposed individuals without this abnormality. The serum level of soluble P-selectin in the SM-exposed group with limbal abnormality was significantly lower than that in the SM-exposed without this abnormality; also it was significantly higher in SM-exposed group with fundus abnormality compared to that in the control group or SM-exposed group without this abnormality. Conclusion The changes in the levels of selectins and ICAM-1 in the SM-exposed group with various ocular abnormalities is a defense mechanism against the toxicity of SM. Further analysis is required to understand the molecular mechanisms of the relationship between adhesion molecules with ocular complications in SM-exposed individuals. |
| Databáze: | OpenAIRE |
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