Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall
| Autor: | Ondřej Bilek, Ivan Čapov, Iva Staniczková Zambo, Michal Benej |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Shoulder Pathology medicine.medical_specialty SDHB Thyroid Nuclear Factor 1 Thyroid Transcription Factor 1 Soft Tissue Neoplasms Mediastinal Neoplasms Pathology and Forensic Medicine Diagnosis Differential Fatal Outcome Predictive Value of Tests Paraganglioma Biomarkers Tumor medicine Humans Malignant Paraganglioma Diagnostic Errors Pathological Aged Paraganglioma Extra-Adrenal business.industry Mediastinum General Medicine medicine.disease Immunohistochemistry Primary tumor Treatment Outcome medicine.anatomical_structure Disease Progression Tomography X-Ray Computed business |
| Zdroj: | Polish Journal of Pathology. 68:354-358 |
| ISSN: | 1233-9687 |
| Popis: | Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary. |
| Databáze: | OpenAIRE |
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