Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the region coding for the carboxyl terminus of the T antigen
| Autor: | Charles N. Cole, H. Van Heuverswyn, Paul Berg, Walter Fiers |
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| Rok vydání: | 1979 |
| Předmět: |
Genes
Viral Base pair Immunology Mutant Simian virus 40 Biology Microbiology Virus Antigen Virology Nucleotide A-DNA Antigens Viral chemistry.chemical_classification Base Sequence Nucleotides Nucleic acid sequence Chromosome Mapping Molecular biology chemistry Genetic Code Insect Science DNA Viral Mutation Research Article Cysteine |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.30.3.936-941.1979 |
| Popis: | Nucleotide sequence analysis of two simian virus 40 early mutants dl1263 and dl1265, which lack a DNA segment around map positions 0.21 and 0.18, respectively (C. Cole, T. Landers, S. Goff, S. MAnteuil-Brutlag, and P. Berg, J. Virol. 24:277--294, 1977), revealed in-phase deletions of 33 nucleotide pairs for dl1263 and 39 nucleotide paris for dl1265. The 33-base-pair deletion in dl1263 does not correspond to an apparent shortening by 6,000 daltons observed for the mutant T antigen. In dl1265 the normal termination signal as well as most of the proline-rich terminal tryptic peptide has been removed, and the carboxyl terminus of the mutant T antigen is a series of three cysteine residues. |
| Databáze: | OpenAIRE |
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