Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease
| Autor: | Miriam Sjåstad Langseth, Trine Baur Opstad, Ragnhild Helseth, A.A. Pettersen, Vibeke Bratseth, Svein Solheim, Ingebjørg Seljeflot, Harald Arnesen |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Extracellular Traps Time Factors Epidemiology Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Thrombophilia Coronary artery disease 03 medical and health sciences 0302 clinical medicine Tissue factor pathway inhibitor Risk Factors medicine Humans Myocardial infarction Blood Coagulation Aged Peroxidase Randomized Controlled Trials as Topic Aged 80 and over Surrogate endpoint business.industry DNA Neutrophil extracellular traps Middle Aged Prognosis medicine.disease Chromatin 030104 developmental biology Immunology Disease Progression Female Cardiology and Cardiovascular Medicine business Cell-Free Nucleic Acids Biomarkers |
| Zdroj: | European Journal of Preventive Cardiology. 25:762-769 |
| ISSN: | 2047-4881 2047-4873 |
| DOI: | 10.1177/2047487318760618 |
| Popis: | Background Neutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis. Design and methods We investigated whether the circulating neutrophil extracellular traps markers, double-stranded DNA and myeloperoxidase-DNA were associated with clinical outcome and hypercoagulability in patients with stable coronary artery disease. Patients with angiographically verified stable coronary artery disease ( n = 1001) were included. Follow-up was 2 years, recording 106 clinical endpoints (unstable angina, non-haemorrhagic stroke, myocardial infarction or death). Serum collected at baseline was used to determine double-stranded DNA and myeloperoxidase-DNA levels. Results The neutrophil extracellular traps markers were weakly intercorrelated ( r = 0.103, P = 0.001). Patients with the highest quartile of double-stranded DNA had weakly but significantly elevated hypercoagulability markers (prothrombin fragment 1+2, D-dimer, free and total tissue factor pathway inhibitor ( P Conclusions Double-stranded DNA levels were significantly related to adverse clinical outcome after 2 years, but only weakly associated with hypercoagulability. These observations suggest that the detrimental effects of neutrophil extracellular traps in coronary artery disease might extend beyond those related to hypercoagulability. |
| Databáze: | OpenAIRE |
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