Age- and Sex-Based Reference Limits and Clinical Correlates of Myocardial Strain and Synchrony
| Autor: | Jayashri Aragam, Ewa Osypiuk, Susan Cheng, Emelia J. Benjamin, Birgitta T. Lehman, Elizabeth L. McCabe, Ramachandran S. Vasan, Scott D. Solomon, Martin G. Larson, Plamen Stanchev |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Heart Ventricles Age and sex Ventricular Function Left Article Sex Factors Framingham Heart Study Predictive Value of Tests Reference Values Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Aged Aged 80 and over Echocardiography Doppler Pulsed business.industry Age Factors Middle Aged Myocardial Contraction Biomechanical Phenomena Surgery Clinical research Blood pressure Predictive value of tests Reference values Multivariate Analysis Myocardial strain Linear Models Cardiology Female Stress Mechanical Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation: Cardiovascular Imaging. 6:692-699 |
| ISSN: | 1942-0080 1941-9651 |
| Popis: | Background— There is rapidly growing interest in applying measures of myocardial strain and synchrony in clinical investigations and in practice; data are limited regarding their reference ranges in healthy individuals. Methods and Results— We performed speckle-tracking–based echocardiographic measures of left ventricular myocardial strain and synchrony in healthy adults (n=739, mean age 63 years, 64% women) without cardiovascular disease. Reference values were estimated using quantile regression. Age- and sex-based upper (97.5th quantile) limits were: −14.4% to −17.1% (women) and −14.4 to −15.2% (men) for longitudinal strain; −22.3% to −24.7% (women) and −17.9% to −23.7% (men) for circumferential strain; 121 to 165 ms (women) and 143 to 230 ms (men) for longitudinal segmental synchrony (SD of regional time-to-peak strains); and 200 to 222 ms (women) and 216 to 303 ms (men) for transverse segmental synchrony. In multivariable analyses, women had ≈1.7% greater longitudinal strain, ≈2.2% greater transverse strain, and ≈3.2% greater circumferential strain ( P P Conclusions— We estimated age- and sex-specific reference limits for measures of left ventricular strain and synchrony in a healthy community-based sample, wherein clinical covariates contributed to only a modest proportion of the variation. These data may facilitate the interpretation of left ventricular strain-based measures obtained in future clinical research and practice. |
| Databáze: | OpenAIRE |
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