Incidence of infective endocarditis in patients considered at moderate risk
| Autor: | Mohsin Aslam, Emil L. Fosbøl, Lauge Østergaard, Henning Bundgaard, G G Gislason, Lars Køber, Niels Eske Bruun, Lars Søndergaard, Andrew Wang, Nana Valeur, Christian Torp-Pedersen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Denmark Population Heart Valve Diseases 030204 cardiovascular system & hematology Lower risk Risk Assessment Heart valve disorder 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Humans Medicine Cumulative incidence Registries 030212 general & internal medicine education Aged Aged 80 and over Heart Valve Prosthesis Implantation education.field_of_study Endocarditis business.industry Incidence Hazard ratio Hypertrophic cardiomyopathy Endocarditis Bacterial Cardiomyopathy Hypertrophic Middle Aged medicine.disease Defibrillators Implantable Aortic Valve Case-Control Studies Heart Valve Prosthesis Infective endocarditis Cardiology Mitral Valve Mitral Valve Disorder Female Moderate-risk patients Cardiology and Cardiovascular Medicine business Follow-Up Studies Endocarditis prophylaxiss |
| Zdroj: | Østergaard, L, Valeur, N, Wang, A, Bundgaard, H, Aslam, M, Gislason, G, Torp-Pedersen, C, Bruun, N E, Søndergaard, L, Køber, L & Fosbøl, E L 2019, ' Incidence of infective endocarditis in patients considered at moderate risk ', European Heart Journal, vol. 40, no. 17, pp. 1355–1361 . https://doi.org/10.1093/eurheartj/ehy629 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehy629 |
| Popis: | Aims Stratification of patients at risk of infective endocarditis (IE) remains a cornerstone in guidance of prophylactic strategies of IE. However, little attention has been given to patients considered at moderate risk. Methods and results Using Danish nationwide registries, we assessed the risk of IE in patients with aortic and mitral valve disorders, a cardiac implantable electronic device (CIED), or hypertrophic cardiomyopathy (HCM) and compared these patient groups with (i) controls from the background population using risk-set matching and (ii) a high-risk population (prosthetic heart valve). Cumulative incidence plots and multivariable adjusted Cox proportional hazard analysis were used to compare risk of IE between risk groups. We identified 83 453 patients with aortic or mitral valve disorder, 50 828 with a CIED, and 3620 with HCM. The cumulative risk of IE after 10 years was 0.9% in valve disorder, 1.3% in CIED, and 0.5% in HCM patients. Compared with the background population, valve disorder, CIED, and HCM carried a higher associated risk of IE, hazard ratio (HR) = 8.75 [95% confidence interval (CI) 6.36–12.02], HR = 6.63 (95% CI 4.41–9.96), and HR = 6.57 (95% CI 2.33–18.56), respectively. All three study groups were associated with a lower risk of IE compared with high-risk patients, HR = 0.27 (95% CI 0.23–0.32) for valve disorder, HR = 0.28 (95% CI 0.23–0.33) for CIED, and HR = 0.13 (95% CI 0.06–0.29) for HCM. Conclusions Heart valve disorder, CIED, and patients with HCM were associated with a higher risk of IE compared with the background population but have a lower associated risk of IE compared with high-risk patients. |
| Databáze: | OpenAIRE |
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