Gene Therapy in Peripheral Artery Disease
| Autor: | M. C. Capogrossi, C. Cirielli, G. Melillo, F. Serino |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Angiogenesis Arterial disease Genetic enhancement Neovascularization Physiologic Disease Bioinformatics Internal medicine medicine Animals Humans Peripheral Vascular Diseases Pharmacology Clinical Trials as Topic business.industry Therapeutic effect Genetic Therapy Hematology Peripheral Clinical trial medicine.anatomical_structure Cardiology Molecular Medicine Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Current Drug Target -Cardiovascular & Hematological Disorders. 4:295-300 |
| ISSN: | 1568-0061 |
| DOI: | 10.2174/1568006043336023 |
| Popis: | In the last decade, studies of the biological mechanisms underlying angiogenesis, i.e. the development of a new vasculature from pre-existing blood vessels, have suggested a new approach to peripheral obstructive artery disease based on the treatment of ischemic tissues with angiogenic growth factors. As demonstrated by experimental studies in animal models, a therapeutic effect can be reached as the newly formed vascular network, functioning as a biologic by-pass, restores a normal blood supply to the ischemic territories. New techniques of gene therapy proved effective in reaching sustained concentrations of angiogenic factors in the target tissues. This review concerns the pre-clinical background and the results of the early clinical trials of angiogenic gene therapy, which have shown the safety and feasibility of this new approach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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