DEVELOPMENT OF CHITOSAN MICROPARTICLES FOR CONTROLLED RELEASE OF METOPROLOL TARTARATE
| Autor: | Mustafa Ergül, Cenk Yıldız, Gülen Melike Demirbolat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
Chromatography business.industry Some limitation media_common.quotation_subject chitosan metoprolol tartarate controlled release microparticles General Medicine Controlled release Dosage form Chitosan Entrapment chemistry.chemical_compound chemistry Health Care Sciences and Services medicine Particle size Sağlık Bilimleri ve Hizmetleri business media_common Metoprolol medicine.drug |
| Zdroj: | Volume: 40, Issue: 4 334-345 Cumhuriyet Medical Journal |
| ISSN: | 1305-0028 |
| Popis: | Hypertension, defined as high blood pressure, is a common medical condition leading to cardiovascular disability and premature deaths. Blood pressure control in an efficient way are assumed to the main targets to prevent hypertension. Since conventional dosage forms (e.g. immediate release tablets, capsules, etc.) show some limitation, greater attention is being paid on designing the modified drug release systems. Modified release is defined as drug releasing from dosage form some time after the administration or in prolonged period of time. In this study, we aimed to design metoprolol tartarate loaded chitosan microparticles to obtained modified drug release. Chitosan microparticles produced via ionic gelation with tripolyphosphate as a crosslinking agent. Prepared formulations were characterized and metoprolol tartarate was loaded into the optimal blank microspheres. The entrapment efficiency, drug loading, cell viability assay and in vitro drug release were investigated. Optimum formulation was spherical and had 81% of yield and 75.373±7.384µm particle size. 16 mg of metoprolol tartarate could be loaded into microparticles and drug release could be maintained for 48 hours. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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