Ovulation Induction for In-Vitro-Fertilization and Embryo Transfer Applying Decapeptyl (DTRP-6 LH/RH) in Combination with HMG or FSH
| Autor: | K. Abd-El Maeboud, K. Semm, H. Steinmüller, Ch. Argiriou, Liselotte Mettler |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
endocrine system Menotropins Injections Subcutaneous Endocrinology Diabetes and Metabolism medicine.medical_treatment media_common.quotation_subject Fertilization in Vitro Luteal phase Chorionic Gonadotropin Gonadotropin-Releasing Hormone Andrology Endocrinology Ovulation Induction Follicular phase Internal Medicine medicine Humans Ovulation media_common Triptorelin Pamoate In vitro fertilisation Dose-Response Relationship Drug business.industry General Medicine Luteinizing Hormone Embryo Transfer Sperm Embryo transfer Luteolytic Agents Pregnancy rate Female Ovulation induction Follicle Stimulating Hormone business |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 92:245-251 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | 47 patients out of the IVF-program of the Department of Obstetrics and Gynecology University of Kiel, who demonstrated in previous stimulation cycles premature LH surges, were treated in two modalities with a down regulation applying the GnRN-analogue decapeptyl (DTRP-6 LH/RH) and a concomitant HMG- or FSH-stimulation. The down-regulation was started after ovulation up to a negative LH/RH test followed by a concomitant gonadotropin stimulation in group 1. In group 2 a parallel treatment with decapeptyl and HMG or FSH was performed from day 2 of the cycle. 10 husbands of the punctured patients had pathological sperm. In both groups 6 patients were discarded from of the stimulation protocol as their oestradiol responses were not adequate, sperm contamination was detected late in one case, and in one patient a premature LH surge occurred once again. In 36 patients vaginal follicular punctures were performed. With respect to pregnancies group 1 revealed a much higher pregnancy rate than group 2. It seemed better to start the down-regulation with the GnRH-analogue decapeptyl in the luteal phase of the previous cycle. The treatment with decapeptyl should not only be applied in patients with previous LH surges but also in order to establish a synchronous follicular maturation in ovulating patients treated for in-vitro fertilization, or gamete-intra-Falloppian-tube-transfer. |
| Databáze: | OpenAIRE |
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