Preclinical assessment of VPEAV, a new trivalent antivenom for elapid snakebite envenoming in the Philippines: Proteomics, immunoreactivity and toxicity neutralization

Autor:	Yi Wei Chan, Kae Yi Tan, Choo Hock Tan
Rok vydání:	2022
Předmět:	Proteomics Elapid Venoms Mice Antivenins Philippines Naja naja Animals Snake Bites Elapidae Toxicology
Zdroj:	Toxicon : official journal of the International Society on Toxinology. 220
ISSN:	1879-3150
Popis:	Snakebite envenoming is an important neglected tropical disease. Antivenom supply, however, remains limited in many parts of the world. This study aimed to examine the protein composition, immunoreactivity and neutralization efficacy of a new antivenom product (VINS Philippine Elapid Antivenoms, VPEAV) developed for the treatment of snakebite envenoming caused by the Philippine Cobra (Naja philippinensis), Samar Cobra (Naja samarensis) and King Cobra (Ophiophagus hannah). Size-exclusion chromatography, sodium-dodecyl sulfate-polyacrylamide gel electrophoresis and tandem mass spectrometry showed that VPEAV consisted of F(ab)'
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae60cc44f3ea5b98c691064b1471a286 https://pubmed.ncbi.nlm.nih.gov/36240856 Zobrazit plný text záznamu Full Text from ScienceDirect