Stress and epilepsy: multiple models, multiple outcomes
| Autor: | Andrew Escayg, Nikki T. Sawyer |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Physiology
Corticotropin-Releasing Hormone Early life stress Models Biological Epilepsy Animal model Multiple Models Adrenocorticotropic Hormone Physiology (medical) Stress (linguistics) medicine Animals Humans Chronic stress Acute stress Seizure frequency business.industry Brain medicine.disease Disease Models Animal Neurology Neurology (clinical) business Corticosterone Neuroscience Stress Psychological |
| Zdroj: | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 27(6) |
| ISSN: | 1537-1603 |
| Popis: | Human studies show a link between stress and epilepsy, with stress causing an increase in seizure frequency and severity in patients with epilepsy. Many different animal model systems have been used to better understand this connection and the possible mechanisms involved. This review highlights the results of such studies relating stress and seizure susceptibility, with a focus on the hypothalamic-pituitary-adrenal axis and its relationship to seizure generation. The effects of hypothalamic-pituitary-adrenal axis mediators, acute stress, chronic stress, and early life stress on the seizure phenotype are summarized. Results suggest that stress has both anticonvulsive and proconvulsive properties, depending on the animal strain and the stress/seizure induction paradigm used. Attempts to interpret the stress-epilepsy literature must take these variables into account. The growing availability of genetically modified mice that carry either human epilepsy mutations or mutations in stress pathway genes now provide the opportunity to examine the relationship between stress and epilepsy more directly. |
| Databáze: | OpenAIRE |
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