Common variants in FOXP1 are associated with generalized vitiligo

Autor:	Pamela R. Fain, Jo Lambert, Christina M. Mailloux, Ying Jin, Stanca A. Birlea, Andreas Overbeck, Alain Taïeb, Margaret R. Wallace, Mauro Picardo, Sheri L. Riccardi, Dorothy C. Bennett, E. Helen Kemp, Paulene J. Holland, Khaled Ezzedine, Wayne T. McCormack, Anthony P. Weetman, Richard A. Spritz, Giovanni Leone, Nanny van Geel, Katherine Gowan, David J. Gawkrodger, Thomas Jouary
Rok vydání:	2010
Předmět:	Linkage disequilibrium Genotype Vitiligo Genome-wide association study Biology Polymorphism Single Nucleotide Article Linkage Disequilibrium 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Gene Frequency Genetic variation Genetics medicine Humans Genetic Predisposition to Disease skin and connective tissue diseases Allele frequency Pigmentation disorder 030304 developmental biology Family Health 0303 health sciences integumentary system Genetic Variation Forkhead Transcription Factors FOXP1 medicine.disease Repressor Proteins Chromosomes Human Pair 3 Genome-Wide Association Study
Zdroj:	Nature genetics
ISSN:	1546-1718 1061-4036
DOI:	10.1038/ng.602
Popis:	In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5f2ad463b3a776f0624cd385289ea9 https://doi.org/10.1038/ng.602 Zobrazit plný text záznamu Plný text ve formátu PDF