Peripheral blood lymphocytes of bipolar affective patients have a histone synthetic profile indicative of an active cell state
| Autor: | Marietta R. Issidorides, Sophia Havaki, George Trikkas, Kalliope E. Sekeri-Pataryas, Thomae G. Sourlingas |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
G2 Phase medicine.medical_specialty Bipolar Disorder Lymphocyte Biology Lymphocyte Activation Resting Phase Cell Cycle S Phase Histones Immune system Reference Values Internal medicine medicine Humans Electrophoresis Gel Two-Dimensional Lymphocytes Bipolar disorder Nuclear protein Biological Psychiatry Aged Pharmacology Analysis of Variance Cell Cycle G1 Phase Middle Aged Cell cycle medicine.disease medicine.anatomical_structure Endocrinology Histone Immunology biology.protein Female Analysis of variance Phosphotungstic acid-haematoxylin stain Biomarkers |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 22:81-96 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/s0278-5846(97)00181-4 |
| Popis: | 1. Although abnormalities of the immune system have been described in depression, no information exists regarding the biochemical parameters which could characterize the physiological state of lymphocytes from patients with bipolar affective disorder. 2. Lymphocytes of normal control subjects are known to be in the Go resting phase of the cell cycle. Histone synthesis is characteristically different during the Go, G1/G2 and the S phases of the cell cycle. As such, it can be used as a biochemical marker with which to distinguish between cycling and noncycling cells. 3. In order to investigate the possibility of whether or not the lymphocytes of patients with bipolar affective disorder are in an activated state, typical of cycling cells, total histone and histone variant synthesis were analysed in peripheral blood lymphocytes of a group of 12 patients with bipolar affective disorder and 7 normal controls. 4. According to the histone variant synthesis pattern, lymphocytes of patients in normothymia have values similar to those of controls, i.e., of noncycling cells, while patients in either the depressed or the manic phase have values intermediate to those of resting and cycling cells. 5. This study shows that histone synthesis can perhaps be used as a biochemical parameter of possible significance in differentiating amongst the three phases of the illness. |
| Databáze: | OpenAIRE |
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