Generalized Recalcitrant Pruritus as the Presenting Manifestation of Hypereosinophilic Syndrome
| Autor: | Marie-Marthe Thibeault, Steve Mathieu, Martin Leblanc, Ariane Schreiber |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Dermatology 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Recurrence Hypereosinophilic Syndrome medicine Eosinophilia Humans Aged Hypereosinophilic syndrome business.industry Pruritus Generalized pruritus medicine.disease Pulmonary embolism Chronic disease 030220 oncology & carcinogenesis Immunology Chronic Disease Surgery Differential diagnosis medicine.symptom business |
| Zdroj: | Journal of cutaneous medicine and surgery. 20(4) |
| ISSN: | 1615-7109 |
| Popis: | Background and Objective: Pruritus is a frequent occurrence in dermatology, and investigation is often unrevealing. The authors report the case of a 65-year-old man presenting with generalized recalcitrant pruritus as the presenting manifestation of hypereosinophilic syndrome. Methods and Results: A 65-year-old man developed intractable pruritus. Results of polymerase chain reaction clonal rearrangement were positive and led to the diagnosis and treatment. The patient also developed massive pulmonary embolism, which can be caused by chronic eosinophilia. Conclusions: This case highlights the importance of investigating patients with pruritus and unexplained persistent eosinophilia. Hypereosinophilic syndrome must be included in the differential diagnosis, which in this case presented initially as intractable pruritus. Polymerase chain reaction clonal rearrangement was key in reinforcing the diagnosis. |
| Databáze: | OpenAIRE |
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