Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Autor: Jari Lahti, Samuli Tuominen, Qiong Yang, Giulio Pergola, Shahzad Ahmad, Najaf Amin, Nicola J. Armstrong, Alexa Beiser, Katharina Bey, Joshua C. Bis, Eric Boerwinkle, Jan Bressler, Archie Campbell, Harry Campbell, Qiang Chen, Janie Corley, Simon R. Cox, Gail Davies, Philip L. De Jager, Eske M. Derks, Jessica D. Faul, Annette L. Fitzpatrick, Alison E. Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J. Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G. Holliday, Peter K. Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J. Knol, Nicole A. Kochan, John B. Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E. Marioni, Karen A. Mather, Sarah Medland, Saira S. Mirza, Mike A. Nalls, Kwangsik Nho, Adrienne O’Donnell, Christopher Oldmeadow, Jodie Painter, Alison Pattie, Simone Reppermund, Shannon L. Risacher, Richard J. Rose, Vijay Sadashivaiah, Markus Scholz, Claudia L. Satizabal, Peter W. Schofield, Katharina E. Schraut, Rodney J. Scott, Jeannette Simino, Albert V. Smith, Jennifer A. Smith, David J. Stott, Ida Surakka, Alexander Teumer, Anbupalam Thalamuthu, Stella Trompet, Stephen T. Turner, Sven J. van der Lee, Arno Villringer, Uwe Völker, Robert S. Wilson, Katharina Wittfeld, Eero Vuoksimaa, Rui Xia, Kristine Yaffe, Lei Yu, Habil Zare, Wei Zhao, David Ames, John Attia, David A. Bennett, Henry Brodaty, Daniel I. Chasman, Aaron L. Goldman, Caroline Hayward, M. Arfan Ikram, J. Wouter Jukema, Sharon L. R. Kardia, Todd Lencz, Markus Loeffler, Venkata S. Mattay, Aarno Palotie, Bruce M. Psaty, Alfredo Ramirez, Paul M. Ridker, Steffi G. Riedel-Heller, Perminder S. Sachdev, Andrew J. Saykin, Martin Scherer, Peter R. Schofield, Stephen Sidney, John M. Starr, Julian Trollor, William Ulrich, Michael Wagner, David R. Weir, James F. Wilson, Margaret J. Wright, Daniel R. Weinberger, Stephanie Debette, Johan G. Eriksson, Thomas H. Mosley, Lenore J. Launer, Cornelia M. van Duijn, Ian J. Deary, Sudha Seshadri, Katri Räikkönen
Přispěvatelé: Epidemiology, Radiology & Nuclear Medicine, VU University medical center, Department of Psychology and Logopedics, University of Helsinki, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Clinicum, Helsinki University Hospital Area, Institute for Molecular Medicine Finland, Department of Public Health, HUSLAB, HUS Helsinki and Uusimaa Hospital District, Cognitive and Brain Aging, Faculty Common Matters (Faculty of Medicine), Centre of Excellence in Complex Disease Genetics, Research Programs Unit, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Medicum
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Molecular Psychiatry, 27, 4419-4431. SPRINGERNATURE
Molecular Psychiatry, 27(11), 4419-4431. Nature Publishing Group
Lahti, J, Tuominen, S, Yang, Q, Pergola, G, Ahmad, S, Amin, N, Armstrong, N J, Beiser, A, Bey, K, Bis, J C, Boerwinkle, E, Bressler, J, Campbell, A, Campbell, H, Chen, Q, Corley, J, Cox, S R, Davies, G, De Jager, P L, Derks, E M, Faul, J D, Fitzpatrick, A L, Fohner, A E, Ford, I, Fornage, M, Gerring, Z, Grabe, H J, Grodstein, F, Gudnason, V, Simonsick, E, Holliday, E G, Joshi, P K, Kajantie, E, Kaprio, J, Karell, P, Kleineidam, L, Knol, M J, Kochan, N A, Kwok, J B, Leber, M, Lam, M, Lee, T, Li, S, Loukola, A, Luck, T, Marioni, R E, Mather, K A, Medland, S, Mirza, S S, Nalls, M A, Nho, K, O'Donnell, A, Oldmeadow, C, Painter, J, Pattie, A, Reppermund, S, Risacher, S L, Rose, R J, Sadashivaiah, V, Scholz, M, Satizabal, C L, Schofield, P W, Schraut, K E, Scott, R J, Simino, J, Smith, A V, Smith, J A, Stott, D J, Surakka, I, Teumer, A, Thalamuthu, A, Trompet, S, Turner, S T, van der Lee, S J, Villringer, A, Völker, U, Wilson, R S, Wittfeld, K, Vuoksimaa, E, Xia, R, Yaffe, K, Yu, L, Zare, H, Zhao, W, Ames, D, Attia, J, Bennett, D A, Brodaty, H, Chasman, D I, Goldman, A L, Hayward, C, Ikram, M A, Jukema, J W, Kardia, S L R, Lencz, T, Loeffler, M, Mattay, V S, Palotie, A, Psaty, B M, Ramirez, A, Ridker, P M, Riedel-Heller, S G, Sachdev, P S, Saykin, A J, Scherer, M, Schofield, P R, Sidney, S, Starr, J M, Trollor, J, Ulrich, W, Wagner, M, Weir, D R, Wilson, J F, Wright, M J, Weinberger, D R, Debette, S, Eriksson, J G, Mosley, T H, Launer, L J, van Duijn, C M, Deary, I J, Seshadri, S & Räikkönen, K 2022, ' Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning ', Molecular Psychiatry, vol. 27, no. 11, pp. 4419-4431 . https://doi.org/10.1038/s41380-022-01710-8
Neurology Working Group of the CHARGE Consortium 2022, ' Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning ', Molecular Psychiatry, vol. 27, no. 11, pp. 4419-4431 . https://doi.org/10.1038/s41380-022-01710-8, https://doi.org/10.1038/s41380-022-01710-8
Molecular psychiatry 27(11), 4419-4431 (2022). doi:10.1038/s41380-022-01710-8
Molecular Psychiatry
ISSN: 1359-4184
DOI: 10.1038/s41380-022-01710-8
Popis: Abstract Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Databáze: OpenAIRE
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