Fluctuation of Viremia in Hepatitis B Virus-Infected Healthcare Workers Performing Exposure-Prone Procedures in the Netherlands
| Autor: | Albert Wong, Stijn F H Raven, Barry de Heus, Jim E. van Steenbergen, Hans L. Zaaijer |
|---|---|
| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention |
| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
Standard interval Adult Male medicine.medical_specialty Hepatitis B virus Infectious Disease Transmission Patient-to-Professional Epidemiology Health Personnel Viremia medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine Occupational Exposure Health care medicine Humans 030212 general & internal medicine Netherlands Retrospective Studies Hepatitis Cross Infection business.industry virus diseases Retrospective cohort study Hepatitis B medicine.disease Virology Occupational Diseases Infectious Diseases lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] 030211 gastroenterology & hepatology Female business Viral load |
| Zdroj: | Infection Control and Hospital Epidemiology, 37, 6, pp. 655-60 Infection control and hospital epidemiology, 37(6), 655-660. Cambridge University Press Infection Control and Hospital Epidemiology, 37, 655-60 |
| ISSN: | 1559-6834 0899-823X |
| Popis: | ObjectiveTo determine the longitudinal changes in viral load of hepatitis B virus (HBV)–infected healthcare workers (HCWs) and its consequences for exclusion of infected HCWs performing exposure-prone procedures, various HBV DNA safety thresholds, and the frequency of monitoring.DesignRetrospective cohort study June 1, 1996–January 31, 2013.ParticipantsIn the Netherlands, chronically HBV-infected HCWs performing exposure-prone procedures are notified to the Committee for Prevention of Iatrogenic Hepatitis B. Of the 126 notified HCWs, 45 had 2 or more HBV DNA levels determined without antiviral therapy.MethodsA time-to-event analysis for HBV-infected HCWs categorized in various viremia levels surpassing a HBV DNA threshold level of 1×105 copies/mL, above which exposure-prone procedures are not allowed in the Netherlands.ResultsFluctuations of HBV DNA in follow-up samples ranged from −5.4 to +2.2 log10 copies/mL. A high correlation was seen for each HBV DNA level with the 3 previous levels. In a time-to-event analysis, after 6 months 7.2%, 6.5%, and 14.3% of individuals had surpassed the threshold of 1×105 copies/mL for viral load categories 4.8×103 to 1.5×104; 1.5×104 to 4.0×104; and 4.0×104 to 1.0×105, respectively.ConclusionsWe propose standard retesting every 6 months, with more frequent retesting just below the high threshold value (1×105 copies/mL), and prolonging this standard interval to 1 year after 3 consecutive levels below the threshold in policies with lower safety thresholds (1×103 or 1×104 copies/mL).Infect Control Hosp Epidemiol 2016;37:655–660 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|