Modified Juvenile Spondyloarthritis Disease Activity Index in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry

Autor: Hemalatha Srinivasalu, Erin Brennan Treemarcki, Dax G. Rumsey, Pamela F. Weiss, Robert A. Colbert
Rok vydání: 2022
Předmět:
Zdroj: The Journal of Rheumatology. 50:532-537
ISSN: 1499-2752
0315-162X
Popis: ObjectiveTo validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA), and modified versions thereof, in a North American cohort of patients with enthesitis-related arthritis (ERA).MethodsWe utilized the Childhood Arthritis and Rheumatology Research Alliance Registry database ERA cohort to validate the JSpADA and its modifications (JSpADA6-no Schober, no C-reactive protein [CRP]/erythrocyte sedimentation rate [ESR]; JSpADA7-no Schober; and JSpADA7-no CRP/ESR) using the Outcome Measures in Rheumatology principles of face validity, discriminative validity, and responsiveness to change.ResultsThere were 51 subjects (64 visits) with complete JSpADA data with a mean age of 13.7 years and disease duration of 30.9 months. Subjects were predominantly White (84.3%), and 56.9% were male and 50% were HLA-B27 positive. The JSpADA showed high correlation with the clinical 10-joint Juvenile Arthritis Disease Activity Score (cJADAS10;r= 0.81), moderate-to-high correlation with physician global assessment (PGA;r= 0.69), and low-to-fair correlation with Childhood Health Assessment Questionnaire (CHAQ;r= 0.22). The modifications of the JSpADA (JSpADA7-no Schober; JSpADA7-no CRP/ESR; and JSpADA6-no Schober, no CRP/ESR) performed similarly with high correlation with cJADAS10 (r= 0.81, 0.79, and 0.80, respectively), moderate-to-high correlation with PGA (r= 0.65, 0.67, 0.64, respectively), and low-to-fair correlation with CHAQ (r= 0.35, 0.34, 0.39, respectively). All modified versions of JSpADA had good responsiveness to change. All versions of JSpADA had excellent discriminative validity.ConclusionWe propose the termmodified JSpADAfor the modification of JSpADA with 6 elements (JSpADA6-no Schober, no CRP/ESR). This shorter disease activity index may improve implementation of JSpADA in both clinical practice and research trials.
Databáze: OpenAIRE
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