Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus
| Autor: | Hiroyuki Arai, Shozo Furumoto, Ren Iwata, Wataru Narita, Shigenori Kanno, Hirokazu Kikuchi, Etsuro Mori, Katsutoshi Furukawa, Toru Baba, Kazuhiko Yanai, Nobuyuki Okamura, Manabu Tashiro, Osamu Iizuka, Kotaro Hiraoka |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Amyloid medicine.medical_specialty Pathology Statistics as Topic Neocortex Japan Alzheimer Disease Internal medicine Biopsy Image Processing Computer-Assisted medicine Humans Aged Retrospective Studies Aged 80 and over Analysis of Variance Benzoxazoles medicine.diagnostic_test business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Comorbidity Cerebrospinal Fluid Shunts Hydrocephalus Normal Pressure Hydrocephalus Thiazoles Neurology Frontal lobe Positron emission tomography Positron-Emission Tomography Cardiology Intracranial pressure monitoring Female Neurology (clinical) Differential diagnosis business |
| Zdroj: | Journal of the Neurological Sciences. 356:124-128 |
| ISSN: | 0022-510X |
| Popis: | Objectives In previous studies, patients with idiopathic normal-pressure hydrocephalus (iNPH) occasionally showed Alzheimer's pathology in frontal lobe cortical biopsy during cerebrospinal fluid shunt surgery or intracranial pressure monitoring. In clinical practice, the differential diagnosis of iNPH from Alzheimer's disease (AD) can be problematic, particularly because some iNPH cases exhibit AD comorbidity. In this study, we evaluated amyloid deposition in the brains of patients with iNPH before shunt surgery, and investigated the association between brain amyloid deposits and clinical improvement following the surgery. Materials & methods Amyloid imaging was performed in patients with iNPH or AD and also in healthy control subjects by using positron emission tomography (PET) and a radiolabeled pharmaceutical compound, 11 C-BF227. Using the cerebellar hemispheres as reference regions, the standard uptake value ratio (SUVR) of the neocortex was estimated and used as an index for amyloid deposition. In patients with iNPH, clinical symptoms were assessed before shunt surgery and 3 months after surgery. Results Five of the 10 patients with iNPH had neocortical SUVRs that were as high as those of AD subjects, whereas the SUVRs of the 5 patients were as low as those of healthy controls. A significant inverse correlation between neocortical SUVRs and cognitive improvements after shunt surgery was observed in iNPH. Conclusions The amount of amyloid deposits ranges widely in the brains of patients with iNPH and is associated with the degree of cognitive improvement after shunt surgery. |
| Databáze: | OpenAIRE |
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