Ketoconazole and Candidiasis: A Controlled Study
| Autor: | Douglas L. Bartley, Gayle G. Patterson, Walter T. Hughes, Haysam Tufenkeji |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Drug
medicine.medical_specialty Antifungal Agents Randomization Adolescent media_common.quotation_subject Placebo Gastroenterology Piperazines Oropharyngeal Candidiasis Random Allocation Double-Blind Method Candidiasis Oral Neoplasms Internal medicine Humans Immunology and Allergy Medicine Child Candida albicans media_common Clinical Trials as Topic biology business.industry Imidazoles Cancer medicine.disease biology.organism_classification Surgery Ketoconazole Infectious Diseases business medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 147:1060-1063 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/147.6.1060 |
| Popis: | A double-blind, placebo-controlled study was undertaken to determine the efficacy of ketoconazole in the treatment of candidiasis. The drug was administered orally in the dosage of 200 mg/m2 of body surface per day for two weeks to cancer patients with oral candidiasis. Randomization in a 2:1 ratio provided 36 patients treated with ketoconazole and 20 managed with a placebo. Regression of visible lesions was achieved in 26 (72%) of 36 ketoconazole-treated and four (20%) of 20 untreated patients; eradication of culturable organisms occurred in 12 (36%) of 33 ketoconazole-treated and one (7%) of 14 untreated patients; and resolution of lesions plus eradication of Candida albicans occurred in nine (25%) of 36 ketoconazole-treated and one (5%) of 20 untreated patients. Although the therapeutic efficacy of ketoconazole was demonstrated for oropharyngeal candidiasis, the magnitude of its efficacy was less than that desired. |
| Databáze: | OpenAIRE |
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