Phospholipase A2 activity in serum of neuroleptic-naive psychiatric inpatients
| Autor: | Meurer H, Klotz J, Albers M, Märki F |
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| Rok vydání: | 1993 |
| Předmět: |
Drug
Adult Male Psychosis medicine.medical_specialty Substance-Related Disorders media_common.quotation_subject Phospholipases A chemistry.chemical_compound Phospholipase A2 medicine Haloperidol Humans Pharmacology (medical) Schizophreniform disorder Neurotransmitter Psychiatry media_common Psychiatric Status Rating Scales biology business.industry General Medicine medicine.disease Psychiatry and Mental health Phospholipases A2 Spectrometry Fluorescence chemistry Psychotic Disorders Schizophrenia biology.protein lipids (amino acids peptides and proteins) business Neuroleptic naive medicine.drug |
| Zdroj: | Pharmacopsychiatry. 26(3) |
| ISSN: | 0176-3679 |
| Popis: | UNLABELLED The activity of phospholipase A2 (PLA2), an enzyme that, besides a number of other functions, is involved in prostaglandin synthesis, regulation of membrane stability, and presynaptic neurotransmitter release, has been reported to be greater in the serum and plasma of schizophrenic patients than in that of other psychiatric patients and normal controls. Furthermore, it is said to be significantly reduced by haloperidol treatment. We decided to replicate these findings in an independent sample of patients by using a highly sensitive assay for determining PLA2 activity.-- METHODS Of 167 consecutive male admissions giving informed consent 35 were found never to have received neuroleptics previously. Ten had DSM-III diagnoses of schizophrenia, schizophreniform disorder, or atypical psychosis, eight of other psychiatric disorders and 17 of alcohol or drug dependence (Table 1). Blood samples were drawn before medication was initiated. For patients still in hospital (Table 3), this was repeated after 21 days of treatment (n = 10). Samples from 10 healthy subjects were also obtained. PLA2 activity was determined according to Marki and Franson (1986), using a radiochemical assay.-- RESULTS On day 0, there were no statistically significant intergroup differences in PLA2 serum activity. After 21 days, it was not possible to detect any significant decrease in PLA2 activity (Table 4). The PLA2 activity of the patient groups did not differ from that of the group of healthy subjects (Table 5).-- CONCLUSION It was not possible to replicate the finding of increased PLA2 activity in schizophrenic patients in our sample of patients never treated with neuroleptics before.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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