Biology and clinical utilization of mesenchymal progenitor cells
| Autor: | Minguell Jj, Paulette Conget, Alejandro Erices |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Physiology
Cell Transplantation Immunology Biophysics Clinical uses of mesenchymal stem cells Bone Marrow Cells Biology Biochemistry Mesoderm immune system diseases medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Progenitor cell lcsh:QH301-705.5 Stem cell transplantation for articular cartilage repair mesenchymal progenitor cells lcsh:R5-920 General Neuroscience Stem Cells Mesenchymal stem cell Cell Biology General Medicine differentiation Cell biology Endothelial stem cell medicine.anatomical_structure lcsh:Biology (General) Bone marrow Stem cell lcsh:Medicine (General) Adult stem cell transplantation Stem Cell Transplantation |
| Zdroj: | BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH Artículos CONICYT CONICYT Chile instacron:CONICYT Brazilian Journal of Medical and Biological Research, Vol 33, Iss 8, Pp 881-887 (2000) Scopus-Elsevier Brazilian Journal of Medical and Biological Research v.33 n.8 2000 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 33, Issue: 8, Pages: 881-887, Published: AUG 2000 |
| ISSN: | 0100-879X |
| Popis: | Within the complex cellular arrangement found in the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal progenitor cells (MPC). These cells can be expanded ex vivo and induced, either in vitro or in vivo, to terminally differentiate into at least seven types of cells: osteocytes, chondrocytes, adipocytes, tenocytes, myotubes, astrocytes and hematopoietic-supporting stroma. This broad multipotentiality, the feasibility to obtain MPC from bone marrow, cord and peripheral blood and their transplantability support the impact that the use of MPC will have in clinical settings. However, a number of fundamental questions about the cellular and molecular biology of MPC still need to be resolved before these cells can be used for safe and effective cell and gene therapies intended to replace, repair or enhance the physiological function of the mesenchymal and/or hematopoietic systems. |
| Databáze: | OpenAIRE |
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