Dynamic Co-evolution of Peptides and Chemical Energetics, a Gateway to the Emergence of Homochirality and the Catalytic Activity of Peptides
| Autor: | Raphaël Plasson, Odile Vandenabeele-Trambouze, Jacques Taillades, Laurent Boiteau, Hélène Collet, Hervé Martin, Jean-Christophe Rossi, Jean-Philippe Biron, Laurence Garrel, Robert Pascal, Eddy Souaid, Grégoire Danger, Franck Selsis, Michel Dobrijevic, Alain Rousset, Auguste Commeyras, Olivier Lagrille |
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| Přispěvatelé: | Aix Marseille Université (AMU), Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Hydrogen cyanide
010402 general chemistry 01 natural sciences Catalysis Mass Spectrometry Ammonia chemistry.chemical_compound 0103 physical sciences Molecule Organic chemistry [CHIM]Chemical Sciences Amino Acids 010303 astronomy & astrophysics Chromatography High Pressure Liquid Ecology Evolution Behavior and Systematics NOx ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification [CHIM.ORGA]Chemical Sciences/Organic chemistry Stereoisomerism General Medicine Isocyanic acid Combinatorial chemistry 0104 chemical sciences Amino acid chemistry Space and Planetary Science Homochirality Peptides |
| Zdroj: | Origins of Life and Evolution of the Biosphere Origins of Life and Evolution of the Biosphere, Springer-Verlag, 2004, 34 (1/2), pp.35-55. ⟨10.1023/B:ORIG.0000009827.54856.59⟩ ResearcherID |
| ISSN: | 0920-9417 1573-0875 |
| Popis: | We propose a scenario for the dynamic co-evolution of peptides and energy on the primitive Earth. From a multi component system consisting of hydrogen cyanide, several carbonyl compounds, ammonia, alkyl amine, carbonic anhydride, borate and isocyanic acid, we show that the reversibility of this system leads to several intermediate nitriles, that irreversibly evolve to alpha-amino acids and N-carbamoyl amino acids via selective catalytic processes. On the primitive Earth these N-carbamoyl amino acids combined with energetic molecules (NOx) may have been the core of a molecular engine producing peptides permanently and assuring their recycling and evolution. We present this molecular engine, a production example, and its various selectivities. The perspectives for such a dynamic approach to the emergence of peptides are evoked in the conclusion. |
| Databáze: | OpenAIRE |
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