Genetic factors associated with the development of age-related macular degeneration
| Autor: | Roman Botov, Olga Sergejeva, Loresa Kriaučiūnienė, Rasa Liutkevičienė |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging genetic structures medicine.medical_treatment Eye disease Disease Audiology Bioinformatics Pathogenesis Diabetes Complications 03 medical and health sciences Macular Degeneration 0302 clinical medicine Diabetes mellitus medicine Prevalence Humans Genetic Predisposition to Disease Obesity Family history Aged Medicine(all) Aged 80 and over lcsh:R5-920 business.industry Macular degeneration genetics 617.736 [udc] Cataract surgery Middle Aged medicine.disease eye diseases Europe Early and late age-related macular degeneration 030104 developmental biology Risk factors Genes Automotive Engineering 030221 ophthalmology & optometry Female sense organs business lcsh:Medicine (General) |
| Zdroj: | Medicina, Wrocław : Elsevier, 2016, vol. 52, no. 2, p. 79-88 Medicina, Vol 52, Iss 2, Pp 79-88 (2016) |
| ISSN: | 1010-660X |
| Popis: | Age-related macular degeneration (AMD) affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people aged more than 60 years. This disease affects 2.5 million individuals in Europe. AMD is caused by both environmental and genetic factors. Numerous risk factors have been reported, but the pathogenesis of AMD is complex and fairly understood. Age, female gender, obesity, race, education status, family history, hyperopia, iris color, cigarette smoking, previous cataract surgery, history of cardiovascular and cerebrovascular disease, diabetes, sunlight exposure and many other factors have been shown to be associated with AMD development. Scientific evidence shows that genes may play a role in the development of nearly 3 out of 4 cases of this devastating eye disease. The genes that have been shown to be associated with AMD are genes encoding complement system components such as CFH, C2, C3, CFB, and other. |
| Databáze: | OpenAIRE |
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