Evaluation of psychoemotional status of rats after brain injury and systemic transplantation of mesenchymal stem cells
| Autor: | L. P. Zhavoronkov, Yu. G. Verkhovskii, E. P. Ananyeva, Kolganova Oi, L. M. Roshal, J. B. Semenova, L. N. Pavlova, V. V. Yuzhakov, A. F. Tsyb, G. N. Souchkevitch, A. S. Shevchuk, A. G. Konoplyannikov, G. A. Lushnikova |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Behavior Animal business.industry Avoidance Conditioning Mesenchymal stem cell Emotions Systemic injection General Medicine Anxiety Autologous bone Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology Rats Transplantation Brain Injuries Shuttle box Avoidance Learning Medicine Animals Rats Wistar business Maze Learning Brain trauma |
| Zdroj: | Bulletin of experimental biology and medicine. 143(4) |
| ISSN: | 0007-4888 |
| Popis: | We studied the effects of systemic transplantation of mesenchymal stem cells obtained after culturing of autologous bone marrow on psychophysiological status of Wistar rats after diffuse brain trauma. Two months after systemic injection of mesenchymal stem cells we observed a decrease in manifestations of emotional behavioral reactions (anxiety and excitability) and shortening of the time of realization of drinking behavior in a T-maze. A significant positive effect of systemic transfusion of mesenchymal stem cells on avoidance conditioning in a shuttle box was observed 3 months after brain injury. |
| Databáze: | OpenAIRE |
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