Risk factors for colorectal neoplasia in persons aged 30 to 39 years and 40 to 49 years
| Autor: | Jung Ho Park, Byung Ik Kim, Yong Kyun Cho, Seungho Ryu, Kyung Eun Yun, Yoon Suk Jung, Woo Kyu Jeon, Hong Joo Kim, Chong Il Sohn, Yoosoo Chang, Dong Il Park |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Colorectal cancer Psychological intervention Colonoscopy Risk Factors Internal medicine Republic of Korea medicine Humans Radiology Nuclear Medicine and imaging Retrospective Studies medicine.diagnostic_test business.industry Fatty liver Gastroenterology Age Factors Middle Aged medicine.disease Obesity Surgery Cross-Sectional Studies Cohort Observational study Female Metabolic syndrome business Colorectal Neoplasms |
| Zdroj: | Gastrointestinal endoscopy. 81(3) |
| ISSN: | 1097-6779 |
| Popis: | Background Very little is known about risk factors associated with colorectal neoplasia in persons aged Objective To investigate risk factors for colorectal neoplasia in persons aged 30 to 39 years and 40 to 49 years and to compare those data with those of persons aged 50 to 59 years. Design Cross-sectional observational study. Setting Screening center in a university hospital in Korea. Patients A cohort of 28,504 Korean adults (13,678 aged 30-39 years, 12,507 aged 40-49 years, and 2319 aged 50-59 years) who underwent colonoscopy as part of their routine preventive health care. Interventions Colonoscopy. Main Outcome Measurements Risk factors for colorectal neoplasia in persons aged 30 to 39 years and 40 to 49 years. Results In the 30-to-39–years group, male sex, smoking, fatty liver, metabolic syndrome (MetS), obesity, elevated fasting blood glucose levels, and elevated triglyceride levels were associated with overall neoplasia, whereas for advanced neoplasia, the independent risk factors were smoking, fatty liver, and elevated triglyceride levels. Moreover, the prevalence of overall neoplasia in men aged 30 to 39 years exhibiting all risk factors was not lower than that in average-risk women aged >50 years (20.8% vs 18.8%; P = .546). The risk factors of overall neoplasia in the 40-to-49–years group were similar to those in the 30-to-39–years group. For advanced neoplasia, the independent risk factors in the 40-to-49–years group were male sex, smoking, MetS, and obesity. Limitations Selection bias may exist for participants of ethnic Korean heritage in 2 centers. Conclusion Obese male smokers with fatty liver and MetS might benefit from screening colonoscopy starting before age 50 years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect