Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: an epidemiological and histological study in 90 asymptomatic patients
| Autor: | Antoine Millon, Mathilde Mura, Philippe Connes, Stéphanie Chanon, Nellie Della-Schiava, Vincent Pialoux, Patrick Lermusiaux, Aurélie Vieille-Marchiset, Pauline Mury, Virginie Nicaise, Diane Collet-Benzaquen, Erica N. Chirico |
|---|---|
| Přispěvatelé: | Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428) (L-VIS), Université de Lyon-Université de Lyon, Laboratoire Technipath, Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Hôpital Edouard Herriot [CHU - HCL], Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Cooper Medical School of Rowan University [Camden] (CMSRU), Institut Universitaire de France, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2019 |
| Předmět: |
Male
[SDV]Life Sciences [q-bio] medicine.medical_treatment physical activity Carotid endarterectomy 030204 cardiovascular system & hematology Metabolic equivalent [SCCO]Cognitive science 0302 clinical medicine Risk Factors Medicine Orthopedics and Sports Medicine 030212 general & internal medicine Stroke ComputingMilieux_MISCELLANEOUS exercise physiology Endarterectomy Aged 80 and over Endarterectomy Carotid education.field_of_study biology cardiovascular Fibrous cap General Medicine Plaque Atherosclerotic Carotid Arteries medicine.anatomical_structure Cardiovascular Diseases Cardiology Female medicine.symptom medicine.medical_specialty Population potential conflict of interest Hemorrhage Physical Therapy Sports Therapy and Rehabilitation Asymptomatic lipids 03 medical and health sciences Internal medicine absence of any commercial or financial relationships that could be construed as a Humans education Exercise Aged business.industry medicine.disease Cross-Sectional Studies Asymptomatic Diseases Histopathology Sedentary Behavior business |
| Zdroj: | British Journal of Sports Medicine British Journal of Sports Medicine, BMJ Publishing Group, 2019, bjsports-2018-099677. ⟨10.1136/bjsports-2018-099677⟩ Br J Sports Med Br J Sports Med, 2019, ⟨10.1136/bjsports-2018-099677⟩ British Journal of Sports Medicine, BMJ Publishing Group, 2020, 54 (8), pp.469. ⟨10.1136/bjsports-2018-099677⟩ |
| ISSN: | 1473-0480 0306-3674 |
| Popis: | ObjectiveCarotid atherosclerotic plaques are a source of emboli for stroke. ‘Unstable’ carotid atherosclerotic plaques may have intraplaque haemorrhages, neovessels, prevalent macrophages, excessive calcium deposits, a large lipid core and a thin fibrous cap. Regular physical activity (PA) may lower the risk of plaques becoming unstable. We evaluated the association of both PA and sedentary behaviour (SB) with carotid plaque histopathology.Methods90 asymptomatic patients who were undergoing carotid endarterectomy for carotid artery narrowing identified on ultrasound reported their PA and SB by questionnaires. We calculated PA intensity in MET (metabolic equivalent of task)-min/week. For analysis, the population was divided into tertiles according to PA (T1PA: the less PA patients; T2PA: the intermediate PA patients; T3PA: the most physically active patients) (T1PAResultsIntraplaque haemorrhage was less frequent in the most physically active tertile (T3PA, 48%) versus T1PA (74%) and in the least sedentary tertile T1SB (50%) versus T3SB (71%). The intraplaque haemorrhage was less frequent in those who exercised more than 900 MET-min/week (59% vs 47% for >900 and ConclusionIn this cross-sectional study of asymptomatic patients who underwent endarterectomy (i) higher reported PA, (ii) intensity of PA and (iii) lower reported SB were associated with lower prevalence of intraplaque haemorrhage. This could be a mechanism whereby PA protects against cerebrovascular disease (stroke) and death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|