Fas-resistance in ATL cell lines not associated with HTLV-I or FAP-1 production
| Autor: | Kazuto Tsuruda, Yasuaki Yamada, Kazuyuki Sugahara, Toshihisa Hayashibara, Tomoko Hata, Kazuo Nohda, Takahiro Maeda, Miyuki Honda, Shimeru Kamihira, Masayuki Tawara, Yoshitsugu Miyazaki, Masao Tomonaga, Tatsuroh Joh |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
Programmed cell death DNA Complementary Leukemia T-Cell Virus Integration viruses Protein Tyrosine Phosphatase Non-Receptor Type 13 Apoptosis DNA Fragmentation Biology Virus immune system diseases Protein Phosphatase 1 hemic and lymphatic diseases Tumor Cells Cultured medicine Humans RNA Messenger fas Receptor Human T-lymphotropic virus 1 Reverse Transcriptase Polymerase Chain Reaction Antibodies Monoclonal medicine.disease Virology Reverse transcriptase In vitro Clone Cells Blotting Southern Leukemia Proto-Oncogene Proteins c-bcl-2 Oncology Drug Resistance Neoplasm Cell culture Cancer research Tumor necrosis factor alpha Protein Tyrosine Phosphatases Carrier Proteins |
| Zdroj: | Cancer Letters. 147:215-219 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(99)00313-4 |
| Popis: | A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) cell lines. SO4, ST1 and KK1 are Fas-sensitive ATL cell lines, and produce small amounts of HTLV-I in vitro. Although their subclones RSO4 and RST1 are completely Fas-resistant, they produced an equivalent amount of HTLV-I to SO4 and ST1. Moreover, FAP-1 mRNA was not detected in these cell lines irrespective of Fas sensitivity. Thus, Fas resistance in ATL cells was not directly associated with the increased production of HTLV-I or FAP-1. |
| Databáze: | OpenAIRE |
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